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pentobarbital will reduce the extent or impact of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will minimize the extent or influence of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Advisable atogepant dosage with concomitant util